ОписаниеAEC-69-8555 GERM-FREE RESEARCH… Radiation induced infection and the role it plays in the radiation syndrome can be significant, particularly for flights deep into space. Germ-free and conventional animals exhibit anatomical, physiological, and immunological differences in response to radiation. In addition to its value for anticipating problems in space flight, research into those phenomena may be useful in explaining the fundamental mechanisms of the action of ionising radiation. Pilot experiments at Berkeley have shown that germ-free mice following exposure to gamma-rays from cobalt-60 have a greater radioresistance than conventional animals. For the space-related biology studies at Berkeley, test animals are kept, and worked with, in germ-free isolators to simulate, the conditions of space. Photo shows two germ-free “isolators” which are kept at a positive pressure with incoming air being sterilised as it passes through multiple layers of spun-glass filter media. A technician is shown introducing a bacterial agent into a sterilised airlock preparatory to transfer of test from, one isolator to the other for a radiation-induced infection experiment. Credit: Lawrence Radiation Laboratory, Berkeley
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